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Chemical mutagen testing on in vivo somatic mammalian cells

  • Models in Toxicology Selected Papers From the International Workshop on Mutagenicity Testing of Drugs and Other Chemicals, Zurich, 2–5 October 1972
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Abstract

Possibilities and limitations in the use of in vivo cytogenetic tests on somatic cells are discussed. Special attention is focused on the problems raised by the relative insensivity of the available procedures. It is emphasized that in planning screening tests the accumulated experience from studies with known chromosome breaking chemicals must be taken into account; theoretical considerations should not override the actual observations. In the Appendix, technical details of the micronucleus test are given. Furthermore, some thoughts are expressed concerning cytogenetic testing on germ cells and embryos.

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References

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Authors and Affiliations

  1. Department of Pediatrics, Division of Medical Genetics, University of Zürich, Kinderspital, CH-8032, Zürich, Switzerland

    W. Schmid

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  1. W. Schmid
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Lecture held at the International Workshop on Mutagenicity Testing of Drugs and Other Chemicals, Zürich, 2–5 October 1972.

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Schmid, W. Chemical mutagen testing on in vivo somatic mammalian cells. Agents and Actions 3, 77–85 (1973). https://doi.org/10.1007/BF01986538

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  • DOI: https://doi.org/10.1007/BF01986538

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